Here is our ranking of the 50 largest banks in the United States. JPMorgan Chase & Co (NYSE: JPM) is the largest U.S. bank in terms of total assets, deposits. In , the bank reported total assets of US$ trillion and posted a net profit US$ billion. Bank of America Corp. Bank of America is one of the largest. Bank of America Corp. Need help with your investments? Inthere were only 4, This long history makes BNY Mellon the oldest banking corporation in the country. And no matter where you live, you can open an online account with a big bank. Insider Intelligence broke down the top 10 banks in the US by assets, with key insights as to how top banks in us by assets got there, where they plan to go in the future, and how smaller banks can compete in the industry. Now operating over 2, branches in 15 states and Washington, D. Breaking into the digital banking industry is key for smaller firms looking to become major US banks.